Rui Ponte Costa
Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Costa, Rui Ponte; Mizusaki, Beatriz E.P.; Jesper Sj�str�m, P.; van Rossum, Mark C. W.
Authors
Beatriz E.P. Mizusaki
P. Jesper Sj�str�m
Prof MARK VAN ROSSUM Mark.VanRossum@nottingham.ac.uk
Chair and Director/Neural Computation Research Group
Abstract
Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts 1) more reliable receptive fields and sensory perception, 2) rapid recovery of forgotten information (memory savings) and 3) reduced response latencies, compared to a model with postsynaptic expression only. Finally we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.
Citation
Costa, R. P., Mizusaki, B. E., Jesper Sjöström, P., & van Rossum, M. C. W. Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Working Paper Type | Working Paper |
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Deposit Date | Sep 28, 2020 |
Publicly Available Date | Feb 8, 2021 |
Public URL | https://nottingham-repository.worktribe.com/output/3020024 |
Publisher URL | https://www.biorxiv.org/content/10.1101/075317v2 |
Additional Information | This is a bioRxiv preprint. |
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075317v2.full
(956 Kb)
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Licence
No License Set (All rights reserved)
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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